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2/A Day Multi . New Multi - Vitamins in a convenient twice daily formulation by Adaptogen Research.

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The majority of commercially available multivitamin and mineral formulas are designed to meet 100% of the RDA or AI, or some percentage thereof. These levels represent the minimum intake required to reduce risk for overt debility, manifested by deficiency diseases such as scurvy or pellagra; they were not derived for the purpose of optimizing health and physiological function, nor reducing risk for age- or lifestyle-related degenerative diseases.(1) 

The optimal intake of vitamins and minerals for the general population remains open for debate and is a topic of ongoing research. For example, since 2001, research by Fenech et al. has investigated the potential to redefine the Australian RDAs for folate, B12, and other micronutrients to levels proven to support healthy DNA replication (also referred to as genomic stability), an important determinant of cellular health.(12-15) Interestingly, the newly proposed Australian RDAs are higher than US RDAs for B12 (7 mcg versus 2.6 mcg) and folate (700 mcg versus 400 mcg), as are the estimated Paleolithic era intakes (see Table 1). This is likely not a coincidence since folate and B12 are necessary for adequate DNA replication, which is in turn critical to successful human evolution.(16)

Other multivitamin and mineral formulas contain ingredients at levels 10-100 times higher than the RDA/AI, based on potential to alleviate genetic polymorphisms affecting nutrient status(2) or to compensate for nutrient depletions resulting from commonly used pharmaceutical drugs. However, with the availability of clinical markers of nutritional deficiencies and genetics-based tests and recommendations, it is no longer necessary to provide such high levels of B vitamins in foundational formulas. Rather, additional nutrients can be supplemented based on relevant tests such as GenomicInsightTM Genomic Health Profile (offered by Diagnostic Solutions). Unlike other DNA tests, GenomicInsightTM enables clinicians to customize reports using the most advanced artificial intelligence, which integrates findings from peer-reviewed research. For example, the levels of vitamins B2, B6, B12 and folate found in TDM are adequate in maintaining healthy homocysteine (Hcy) levels for some individuals but not for those with single nucleotide polymorphisms on particular Hcy metabolic pathways and/or folate receptor activity.(20-22) The GenomicInsight™ report identifies which of these nutrients are required in higher doses in order to normalize Hcy levels. Other nutritionally relevant tests include NutrEval® (offered by Genova Diagnostics) and ALCAT Functional Cellular Assays (By Cell Science Systems).

2/A Day Multi is a two-a-day multivitamin designed to provide nutrients that are difficult to obtain in the typical daily diet. Its formulation has been guided by principles of evolutionary biology and human physiological adaptation to a whole food, nutrient-dense diet that supplies adequate energy, guided additionally by common nutrient insufficiencies in the US and by criteria beyond the established Recommended Dietary Allowances (RDAs) and Adequate Intakes (AIs). TDM includes a tocopherol-free form of vitamin E Isomers, a blend of gamma and delta-tocotrienols, which have unique health and healthy aging benefits, and a unique blend of vitamin K1 with various forms of vitamin K2. It also includes a natural form of folate that addresses common genetic polymorphisms, and an effective dose of vitamin B12 to help overcome various malabsorption syndromes.

Comparison of 2/A Day Multi, estimated Paleolithic diets, average US intakes and US RDA/AI 

Table 1 (see link on back) compares the ingredients in 2/A Day Multi to estimated dietary intakes of the corresponding nutrients during the Paleolithic era, the current US RDA/AI, and average US intakes (based on data from NHANES 2001-2002).(40) The estimated Paleo era nutrient intakes are based on values reported by Cordain,(6) a recalculation of Cordain’s data with more advanced nutrition analysis software, and the evaluation of another sample Paleo diet.(17-19) The data in Table 1 show that average Paleo nutrient intakes are significantly higher than current US RDA/AI, except for molybdenum. A twocapsule serving of 2/A Day Multi offers comparable amounts of essential micronutrients to those found in a 2000 kcal “Paleo-like” diet, with some adjustments based on average US intakes, nutrient bioavailability, and upper tolerable levels. Magnesium, calcium, iron and copper are not included in TDM because this formula is designed to allow for more flexible and individualized supplementation of these nutrients. They may be derived from the diet or from condition-specific formulas or various mineral formulas. Healthcare practitioners may recommend additional supplements based on patients’ diets, lifestyle factors and clinical evaluations.


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