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DHQ Allergy is the best solution for the sniffles, sneezing and watery eyes.

Allergy DHQ incorporates bioflavonoids, micronutrients, proteolytic enzymes, and herbs into a comprehensive formula that provides multifaceted support for individuals with immune imbalances. Dihydroquercetin, a key component in Allergy DHQ, inhibits oxidation, is bioactive, and is highly absorbable. Allergy DHQ supports the body’s regulating function in addressing an overactive or distressed histamine response that are sometimes brought on by the environment.*

Vitamin C (ascorbic acid) Vitamin C is essential to humans and must be obtained exogenously. While most mammals are able to synthesize ascorbic acid, humans lack one of the enzymes required for this process and can quickly become deficient if dietary or supplemental intake is inadequate. Stress, smoking, pollution, and temperature changes increase our requirement for vitamin C. Wellknown functions of vitamin C include antioxidant protection from damaging free radicals and the synthesis of collagen, carnitine, and neurotransmitters. Vitamin C also plays a lesser-known role in the deactivation of histamine.*[2,3&91; 

Bioflavonoids Quercetin, dihydroquercetin (DHQ), and rutin are active bioflavonoids incorporated into Allergy DHQ for their role in moderating an exaggerated immune response. Bioflavonoids work synergistically with other antioxidants to protect tissues from the negative effects of oxidation and inflammation often observed during hyperimmune reactions.[4&91; Immune-moderating effects include inhibition of mastcell degranulation and prevention of histamine release during hypersensitive episodes.*[1,5,6&91; 

Dihydroquercetin DHQ supports the activities of other antioxidants, protects erythrocytes and capillaries, supports bronchial function, and assists in chelation of metals.[7&91; DHQ was also found to moderate proinflammatory pathways by inhibiting inducible ICAM-1 expression.[8&91; The FlavitPURE™† form of DHQ in Allergy DHQ is a bioactive, natural form that is significantly more absorbable than quercetin alone. The inclusion of FlavitPURE in Allergy DHQ creates a clear advantage over products containing only quercetin, as fewer capsules are required for effective results. This specific form of DHQ boasts an impressive ORAChydro value of 28,000+ μM TE/g and a CAP-e assay of 9.9-10.5 units per gram,[7,9&91; indicative of effective antioxidant protection within the cell. ORAChydro reflects oxygen radical absorbance capacity for water-soluble antioxidants, and CAP-e refers to cell-based antioxidant protection in erythrocytes.*

Rutin A source of naturally occurring flavonoids, rutin reduces capillary permeability and edema, which can reduce mucus fluid buildup or “runny nose.”[10&91; Rutin’s protective effect against oxidation is amplified by ascorbic acid, also present in AllerDHQ.*[4&91;

N-Acetyl-Cysteine NAC is the acetylated form of the conditionally essential amino acid L-cysteine. As a precursor to the “master antioxidant” glutathione, NAC plays a significant role in detoxification and antioxidant protection. NAC also functions as a natural mucolytic, reducing the viscosity of mucus commonly produced during a hyperimmune response.*[11,12&91; 

Stinging Nettle Extract (Urtica dioica) Stinging nettle leaf has been found to regulate a variety of inflammatory activities associated with hyperimmune response, including mast-cell degranulation, prostaglandin formation, and histamine action.*[13-15&91; 

Bromelain Bromelain refers to an enzyme complex extracted from the stem and fruit of the pineapple plant (Ananas comosus). Its modulation of the inflammatory response is thought to exert a beneficial effect in combating hypersensitive immune reactions, earning it approved status by the German Commission E for “micro-inflammations” and related discomforts.[15,16&91; Early studies identified its positive effects on controlling edema, tissue permeability, and vasodilation.[17&91; Bromelain is also found to enhance the absorption of quercetin.*[18&91; Research indicates that the natural components in Allergy DHQ, including vitamin C, bioflavonoids, DHQ, NAC, and bromelain, work synergistically to moderate unpleasant immune reactions.

FORMULATED TO EXCLUDE: Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

 This product contains a unique combination of three bioactive, health-promoting curcuminoids: curcumin, bisdemethoxy curcumin and demethoxy curcumin, along with turmeric oil. The three curcuminoids are the strongest, most protective and best researched constituents of the turmeric root. Naturally occurring turmeric root powder contains only 5-7% curcumin, while the blend in Bio-Curcumin Plus is concentrated to contain 95% curcuminoids, of which curcumin represents 70%. 

The crystalline structure of curcumin renders it difficult to absorb in the GI tract. According to researchers, “The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination.”[1&91;  For this reason, Bio-Curcumin is manufactured using the new process, which is an all-natural formulation that improves the absorption and delivery of curcumin. This process uses a proprietary blend of turmeric oil, sunflower lecithin, and vitamin E, without the use of potentially harmful surfactants. This delivery technology increases the absorption rate and reduces the absorption time for nutrients and may allow for superior effects through lower dosages. 

Bio-Curcumin is unique in that it has been shown to increase tetrahydrocurcumin as well as curcumin, demethoxycurcumin and bisdemethoxycurcumin in plasma. Tetrahydrocurcumin is a major metabolite of curcumin and demonstrates remarkable antioxidant properties exceeding those of curcumin alone.2-4 Compared to reference products containing equal concentrations of curcuminoids, Curcum-Evail® exhibited several-fold higher absorption, resulting in plasma levels of tetrahydrocurcumin that were nearly 30 times higher. Area under the curve (AUC) amounts for plasma levels of all three curcuminoids in this formula were significantly higher than for the reference products.

Curcumin and the Inflammatory Response 

Excessive inflammation is a common risk factor for disease occurrence and progression. Inflammation may lead to joint tissue destruction, cancer, cardiovascular events, insulin resistance/diabetes and brain/liver/kidney degenerative diseases. Research shows curcumin helps support a healthy inflammatory response.12 It was shown to reduce both acute and chronic inflammation caused by physical injury, joint wear and tear (as in osteoarthritis), chronic infections or inadequate antioxidant protection.[5-8, 12, 18, 19, 22, 60&91;

Curcumin was shown to be more effective than certain NSAIDs in reducing inflammation and pain associated with rheumatoid arthritis19 or post-operative trauma56. It has a better cardiovascular safety profile than aspirin because, unlike aspirin, it does not inhibit the arterial protective factor prostacyclin.22 Curcumin acts on the mother compound NF Kappa beta. By suppressing this inflammatory marker, curcumin has a domino effect that reduces the entire cascade of inflammatory compounds that would be produced thereafter. 

Curcumin has an advantage over pharmacological anti-inflammatory agents because it is a powerful antioxidant, so it can also reduce COX expression along with being a COX 1 and COX 2 inhibitor. Where NSAIDs are known to have potential GI side effects such as GI bleeding, one study showed that curcumin was able to heal GI injury caused by the NSAID indomethacin.[8&91;  Amazingly, curcumin and resveratrol have been proven to be even stronger anti-inflammatories than ibuprofen and aspirin.[7&91;

Allergies and Histamine Release 

Curcumin has been shown to decrease histamine release, suggesting that it plays a significant role in exerting both antioxidative and antiallergic activities.[9&91;  Research shows that curcumin's potential beneficial effect on the allergic response works by inhibiting the production of cytokines affecting eosinophil function and IgE synthesis.[10&91;

Autoimmune Conditions 

Curcumin downregulates mediators characteristic of rheumatoid arthritis,[19&91; reduces disease activity in Crohn's[13&91; and was shown to reduce disease activity in a model of multiple sclerosis in animals.[32&91;

“These findings highlight the fact that curcumin inhibits experimental encephalomyelitis by blocking IL-12 signaling in T cells and suggest its use in the treatment of MS and other Th1 cell-mediated inflammatory diseases.”[32&91;

By boosting NK cell activity increase,6 curcumin may also enhance the body's ability to fight infections.

Additional Research 

There are many studies on curcumin and cancer. For patients undergoing chemotherapy, curcumin does not need to be avoided as it has been shown to enhance chemotherapy effectiveness.[52&91; Curcumin was the highlight of human clinical trials performed at the M.D. Anderson Cancer Institute in Houston, Texas. 

“In addition to antioxidation, curcumin could also induce apoptosis by targeting mitochondria, affecting p53-related signaling and blocking NF-kappaB activation. To further dissect its anticarcinogenic mechanisms, a number of curcumin targets were identified. These included the aryl hydrocarbon receptor, cytochrome P450, glutathione S-transferase, serine/threonine kinases, transcription factors, cyclooxygenase, ornithine decarboxylase, nitric oxide synthase, matrix metalloproteinases and tyrosine kinases.”[44&91; 

Many spices protect the body from bacteria and parasites in food, while boosting the body’s antioxidant abilities. Research shows curcumin to have antimicrobial activities. Curcumin was shown to reduce transcription of Epstein Barr[25&91; and HIV virus[26,27&91;. Curcumin may work to inhibit the growth of Staphylococcus aureus, Staphylococcus albus, and Bacillus typhosus, and is also effective against nematode parasites and certain protozoa.[4,5&91; 

 GI Protection 

Curcumin may benefit ulcer, proctitis (inflammation of the rectum common in ulcerative colitis and Crohn's disease) and may reduce leaky gut syndrome.

“We conclude that antiulcer activity of curcumin is primarily attributed to matrix metalloproteinases -9 inhibition, one of the major path-ways of ulcer healing.”[8&91;  “A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates.” [13&91; 

Cardiovascular Protection 

Curcumin may lower total cholesterol, fibrinogen and platelet aggregation, while increasing HDL and decreasing lipid peroxidation.[30, 38, 22, 41&91; 

In one study, “The effect of curcumin administration in reducing the serum levels of cholesterol and lipid peroxides was studied in ten healthy human volunteers, receiving 500 mg of curcumin per day for 7 days. A significant decrease in the level of serum lipid peroxides (33%), increase in HDL Cholesterol (29%), and a decrease in total serum cholesterol (11.63%) were noted.”[30&91; According to another study, “Our reviewed data show that, in human healthy subjects, the daily intake of 200 mg of the above extract results in a decrease in total blood lipid peroxides as well as in HDL and LDL-lipid peroxidation. This anti-atherogenic effect was accompanied by a curcuma antioxidant-induced normalization of the plasma levels of fibrinogen and of the apo B/apo A ratio, that may also decrease the cardiovascular risk.” [38&91; 

Brain Protection 

Curcumin pretreatment reduced brain damage following ischemia/stroke [51&91; and from heavy alcohol intake.[54&91; Curcumin reduced development and severity of Alzeimer's disease in animal models by reducing plaque aggregation and plaque induced oxidative stress and was even capable of dissociating existing plaque.[21&91; Its chelating ability for iron and copper ions is also believed to play a beneficial role in reducing the progression of the disease.[57&91;

“Initially, we reported the impact of non-steroidal anti-inflammatory drugs (NSAIDs), notably ibuprofen, which reduced amyloid accumulation, but suppressed few inflammatory markers and without reducing oxidative damage. Safety concerns with chronic NSAIDs led to a screen of alternative NSAIDs and identification of the phenolic anti-inflammatory/anti-oxidant compound curcumin, the yellow pigment in turmeric that we found targeted multiple AD pathogenic cascades. The dietary omega-3 fatty acid, docosahexaenoic acid (DHA), also limited amyloid, oxidative damage and synaptic and cognitive deficits in a transgenic mouse model. Both DHA and curcumin have favorable safety profiles, epidemiology and efficacy, and may exert general anti-aging benefits (anti-cancer and cardioprotective.)”[50&91;

Liver Protection 

Curcumin pretreatment was shown to reduce the liver damage induced by alcohol58 and aflatoxin59 (the fungal toxin often found along with peanuts/peanut butter).

References 

1. Jäger R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutrition Journal. 2014;13:11. 

2. Osawa T, Sugiyama Y, Inayoshi M, Kawakishi S. Antioxidative activity of tetrahydrocurcuminoids. Biosci Biotechnol Biochem. 1995 Sep;59(9):1609-12. 

3. Lai CS, Wu JC, Yu SF, Badmaev V, Nagabhushanam K, Ho CT, Pan MH. Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis. Mol Nutr Food Res. 2011 Dec;55(12):1819-28. 

4. Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida K, Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr. 2001 Aug;131(8):2090-5.

5. Araujo CC, Leon LL.Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001 Jul;96(5):723-8.

6. Yadav VS, Mishra KP, Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol. 2005;27(3):485-97. 

7. Takada Y, Bhardwaj A. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9;23(57):9247-58. 

8. Swarnakar S, Ganguly K.Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. 

9. Suzuki M, Nakamura T. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull. 2005 Aug;28(8):1438-43. 

10. Kobayashi T, Hashimoto S Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem Pharmacol. 1997 Oct 1;54(7):819-24. 

11. Yamamoto H, Hanada K. Inhibitory effect on curcumin on mammalian phospholipase D activity. FEBS Lett. 1997 Nov 10;417(2):196-8. 

12. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8. 

13. Holt PR, Katz S Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005 Nov;50(11):2191-3. 

14. Heck AM, et al. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Jul2000;57(13):1221-7. 

15. Reddy AC, et al. Effect of Dietary Turmeric (Curcuma longa) on Iron-induced Lipid Peroxidation in the Rat Liver. Food Chem Toxicol. Mar1994;32(3):279-83. 

16. Subramanian M, et al. Diminution of Singlet Oxygen-induced DNA Damage by Curcumin and Related Antioxidants. Mutat Res. Dec1994;311(2):249-55. 

17. Ruby AJ, et al. Anti-tumour and Antioxidant Activity of Natural Curcuminoids. Cancer Lett. Jul1995;94(1):79-83. 18. Ammon HP, et al. Mechanism of Anti-inflammatory Actions of Curcumin and Boswellic Acids. J Ethnopharmacol. 1993;38:113. 

19. Deodhar SD, et al. Preliminary Studies on Anti-Rheumatic Activity of Curcumin. Ind J Med Res. 1980;71:632. 

20. Xu Y, Ku BS, The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol. 2005 Jul 25;518(1):40-6. 

21. Yang F, Lim GP. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7. 

22. Srivastava V, et al. Effect of Curcumin on Platelet Aggregation and Vascular Prostacyclin Synthesis. Arzneim Forsch/Drug Res. 1986;36:715-17. 

23. Mehta K, et al. Antiproliferative Effect of Curcumin (Diferuloylmethane) against Human Breast Tumor Cell Line. Anticancer Drugs. Jun1997;8(5):470-81. 

24. Rao CV, et al. Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound. Cancer Res. Jan1995;55(2):259-66. 

25. Ranjan D, et al. The Effect of Curcumin On Human B-Cell Immortalization by Epstein-Barr Virus. Am Surg. Jan1998;64(1):47-51. 

26. Mazumder A, et al. Inhibition of Human Immunodefficiency Virus Type-I Integrase by Curcumin. Biochem. Pharmacol. 1995;49(11):1165-70. 

27. Barthelemy S, et al. Curcumin and Curcumin Derivatives Inhibit Tat-mediated Transactivation of Type 1 Human Immunodeficiency Virus Long Terminal Repeat. Res Virol. Jan1998;149(1):43-52.

28. Kawamori T, et al. Chemopreventive Effect of Curcumin, A Naturally Occurring Anti-inflammatory Agent, During the Promotion/Progression Stages of Colon Cancer. Cancer Res. Feb1999;59(3):597-601. 

29. Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer. Sep2002;95(6):1206-14. 

30. Soni KB, et al. Effect of Oral Curcumin Administration on Serum Peroxides and Cholesterol Levels in Human Volunteers. Indian J Physiol Pharmacol. Oct1992;36(4):273-75.

31. Sharma OP. Antioxidant Activity of Curcumin and Related Compounds. Biochem Pharmacol. 1976;46:1013. 

32. Natarajan C, Bright JJ Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol. 2002 Jun 15;168(12):6506-1329. 

33. Kim SY, Jung SH. Kim HS. Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem Biophys Res Commun. 2005 Nov 18;337(2):510-6. Epub 2005 Sep 21. 

34. Danilenko M, Studzinski GP.. Enhancement by other compounds of the anti-cancer activity of vitamin D(3) and its analogs. Exp Cell Res. 2004 Aug 15;298(2):339-58. 

35. Sharma RA, McLelland HR, Hill KA, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 2001;7:1894-900. 

36. Zhang F, Altorki NK, Mestre JR, et al. Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis 1999;20:445-51. 

37. Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 2002;40:1091-7. 

38. Miquel J, Bernd A, The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr. 2002 Feb;34(1):37-46. 

39. Deeb D, Xu YX, Jiang H, et al. Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol Cancer Ther 2003;2:95-103. 

40. Thaloor D, Singh AK, Sidhu GS, et al. Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth Differ 1998;9:305-12. 

41. Shah BH, Nawaz Z, Pertani SA. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol 1999;58:1167-72. 

42. Thamlikitkul V, Bunyapraphatsara N, Dechatiwongse T, et al. Randomized double blind study of Curcuma domestica Val. for dyspepsia. J Med Assoc Thai 1989;72:613-20. 

43. Rasyid A, Rahman AR, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr 2002;11:314-8. 

44. Leu TH, Maa MC.The molecular mechanisms for the antitumorigenic effect of curcumin. Curr Med Chem Anti-Canc Agents. 2002 May;2(3):357-70. 

45. Antony S, Kuttan R, Kuttan G. Immunomodulatory activity of curcumin. Immunol Invest 1999;28:291-303.

46. Kuttan R, Sudheeran PC, Josph CD. Turmeric and curcumin as topical agents in cancer therapy. Tumori 1987;73:29-31.

47. Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol. 2001 Jun;39(6):541-7. 

48. Lal B, Kapoor AK, Asthana OP, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res 1999;13:318-22. 

49. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxy genase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 2004 Oct 18. 

50. Cole GM, Lim GP, Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Oct 30; [Epub ahead of print&91; 

51. Wang Q, Sun AY, Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci Res. 2005 Oct 1;82(1):138-48. 

52. Chan MM, Fong D. Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents. J Cell Physiol. 2003 Jan;194(1):63-70. 

53. Zheng L, Tong Q. Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms. J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):55-8. 

54. Rajakrishnan V, Viswanathan P Neuroprotective role of curcumin from curcuma longa on ethanol-induced brain damage. Phytother Res. 1999 Nov;13(7):571-4. 

55. Rajakrishnan V, Jayadeep A. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr Biochem. 2000 Oct;11(10):509-14 

56. Satoskar RR, Shah SJ. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol.1986 Dec;24(12):651-4. 

57. Baum L, Ng A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J Alzheimers Dis. 2004 Aug;6(4):367-77. 

58. Rajakrishnan V, Jayadeep A. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr Biochem. 2000 Oct;11(10):509-14 

59. Soni KB, Rajan A. Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett. 1992 Sep 30;66(2):115-21. 

60. Schulze-Tanzil G. Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci. 2004 Dec;1030:578-86.

Vitamin C, or ascorbic acid, is a water-soluble vitamin. This means that it dissolves in water and is delivered to the body’s tissues but is not well stored, so it must be taken daily through food or supplements. [2&91;

Vitamin C plays a role in controlling infections and healing wounds, and is a powerful antioxidant that can neutralize harmful free radicals. It is needed to make collagen, a fibrous protein in connective tissue that is weaved throughout various systems in the body: nervous, immune, bone, cartilage, blood, and others. The vitamin helps make several hormones and chemical messengers used in the brain and nerves. [3&91;

Ultra Vitamin C 1000

C Fizz

References

1. Br J Nutr. 2002 Nov;88 Suppl 2:S165-77.doi: 10.1079/BJN2002682.The immune system: a target for functional foods?

2.Carpenter KJ. The history of scurvy and vitamin C. Cambridge: Cambridge University Press, 1986.

3.Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington (DC): National Academies Press (US); 2000.

The use of Bergamot for Non-Alcoholic Steatohepatitis-
Recent evidence shows that bergamot polyphenolic fraction (BPF) in patients with Metabolic Syndrome and NASH induces a significant reduction.

•Reduced SteatoTest
•Reduced hepatorenal index
•Reduced C-reactive protein (Hs-CRP)
•Reduced ALT and AST serum aminotransferases
•Reduced gamma-GT enzyme
•Reduced TNF-α inflammation marker

Research has suggested that Bergamot Polyphenolic Fraction Gold (BPFG®) is utilized hepatically to help maintain healthy cholesterol levels already within normal range and to support healthy blood glucose metabolism.

Clinical Applications

» Elevated Lipids
» Triglycerides Lowering
» A favorable shift in LDL and HDL particle size
» Reduced steato test, liver enzymes and overall liver support
» Reduced Hs-CRP
» BPF enhanced Crestor Induced Effects

Something magical happens to 47% Bergamot when you combine it with CAPROS a patented extract of AMLA Fruit. ALMA from gooseberry extract is one of the hottest researched extracts right now in Functional Medicine and below you can see why.

Combines the antioxidant activity of bergamot (Citrus bergamia) with the superfruit of amla!

More info on Phyllanthus emblica Goose Berry Extract:

Human clinical studies show that Capros improves endothelial function, lipid profile, and blood flow and increases production of nitric oxide. It has significant effects in modulating markers of metabolic health and mitigated the effects of stress-induced cardiovascular changes in healthy volunteers. ~VEGAN, certified organic~

Clinical Applications
» Elevated Lipids
» Triglycerides Lowering
» Improved Endothelial Function
» Blood Pressure
» Significant Improvements in Glutathione and Nitric Oxide production
» A favorable shift in LDL and HDL particle size
» Improved Blood Flow by inhibiting platelet aggregation
» Reduced Hs-CRP
» Metabolic Syndrome and Insulin Resistance

DRS Sheet

The majority of commercially available multivitamin and mineral formulas are designed to meet 100% of the RDA or AI, or some percentage thereof. These levels represent the minimum intake required to reduce risk for overt debility, manifested by deficiency diseases such as scurvy or pellagra; they were not derived for the purpose of optimizing health and physiological function, nor reducing risk for age- or lifestyle-related degenerative diseases.(1) 

The optimal intake of vitamins and minerals for the general population remains open for debate and is a topic of ongoing research. For example, since 2001, research by Fenech et al. has investigated the potential to redefine the Australian RDAs for folate, B12, and other micronutrients to levels proven to support healthy DNA replication (also referred to as genomic stability), an important determinant of cellular health.(12-15) Interestingly, the newly proposed Australian RDAs are higher than US RDAs for B12 (7 mcg versus 2.6 mcg) and folate (700 mcg versus 400 mcg), as are the estimated Paleolithic era intakes (see Table 1). This is likely not a coincidence since folate and B12 are necessary for adequate DNA replication, which is in turn critical to successful human evolution.(16)

Other multivitamin and mineral formulas contain ingredients at levels 10-100 times higher than the RDA/AI, based on potential to alleviate genetic polymorphisms affecting nutrient status(2) or to compensate for nutrient depletions resulting from commonly used pharmaceutical drugs. However, with the availability of clinical markers of nutritional deficiencies and genetics-based tests and recommendations, it is no longer necessary to provide such high levels of B vitamins in foundational formulas. Rather, additional nutrients can be supplemented based on relevant tests such as GenomicInsightTM Genomic Health Profile (offered by Diagnostic Solutions). Unlike other DNA tests, GenomicInsightTM enables clinicians to customize reports using the most advanced artificial intelligence, which integrates findings from peer-reviewed research. For example, the levels of vitamins B2, B6, B12 and folate found in TDM are adequate in maintaining healthy homocysteine (Hcy) levels for some individuals but not for those with single nucleotide polymorphisms on particular Hcy metabolic pathways and/or folate receptor activity.(20-22) The GenomicInsight™ report identifies which of these nutrients are required in higher doses in order to normalize Hcy levels. Other nutritionally relevant tests include NutrEval® (offered by Genova Diagnostics) and ALCAT Functional Cellular Assays (By Cell Science Systems).

2/A Day Multi is a two-a-day multivitamin designed to provide nutrients that are difficult to obtain in the typical daily diet. Its formulation has been guided by principles of evolutionary biology and human physiological adaptation to a whole food, nutrient-dense diet that supplies adequate energy, guided additionally by common nutrient insufficiencies in the US and by criteria beyond the established Recommended Dietary Allowances (RDAs) and Adequate Intakes (AIs). TDM includes a tocopherol-free form of vitamin E Isomers, a blend of gamma and delta-tocotrienols, which have unique health and healthy aging benefits, and a unique blend of vitamin K1 with various forms of vitamin K2. It also includes a natural form of folate that addresses common genetic polymorphisms, and an effective dose of vitamin B12 to help overcome various malabsorption syndromes.

Comparison of 2/A Day Multi, estimated Paleolithic diets, average US intakes and US RDA/AI 

Table 1 (see link on back) compares the ingredients in 2/A Day Multi to estimated dietary intakes of the corresponding nutrients during the Paleolithic era, the current US RDA/AI, and average US intakes (based on data from NHANES 2001-2002).(40) The estimated Paleo era nutrient intakes are based on values reported by Cordain,(6) a recalculation of Cordain’s data with more advanced nutrition analysis software, and the evaluation of another sample Paleo diet.(17-19) The data in Table 1 show that average Paleo nutrient intakes are significantly higher than current US RDA/AI, except for molybdenum. A twocapsule serving of 2/A Day Multi offers comparable amounts of essential micronutrients to those found in a 2000 kcal “Paleo-like” diet, with some adjustments based on average US intakes, nutrient bioavailability, and upper tolerable levels. Magnesium, calcium, iron and copper are not included in TDM because this formula is designed to allow for more flexible and individualized supplementation of these nutrients. They may be derived from the diet or from condition-specific formulas or various mineral formulas. Healthcare practitioners may recommend additional supplements based on patients’ diets, lifestyle factors and clinical evaluations.

References 

1. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes. National Academy Press, Washington, DC, 2001. 

2. Ames BN. Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. J Nucleic Acids. 2010 Sep 22;2010. pii: 725071. doi: 10.4061/2010/725071. PubMed PMID: 20936173; PubMed Central PMCID: PMC294568. 

3. Lucock MD, Martin CE, Yates ZR, Veysey M. Diet and our genetic legacy in the recent anthropocene: a Darwinian perspective to nutritional health. J Evid Based Complementary Altern Med. 2014 Jan;19(1):68-83. doi: 10.1177/2156587213503345. Epub 2013 Sep 12. Review. PubMed PMID: 24647381. 

4. Kuipers RS, Joordens JC, Muskiet FA. A multidisciplinary reconstruction of Palaeolithic nutrition that holds promise for the prevention and treatment of diseases of civilisation. Nutr Res Rev. 2012 Jun;25(1):96-129. doi: 10.1017/S0954422412000017. Review. PubMed PMID: 22894943. 

5. Jew S, AbuMweis SS, Jones PJ. Evolution of the human diet: linking our ancestral diet to modern functional foods as a means of chronic disease prevention. J Med Food. 2009 Oct;12(5):925-34. doi: 10.1089/ jmf.2008.0268. Review. PubMed PMID: 19857053. 

6. Cordain L., The Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups., JANA Vol. 5, No. 3, 2002., 14-24. 

7. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC Jr, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2009 Aug;63(8):947-55. doi: 10.1038/ejcn.2009.4. Epub 2009 Feb 11. Erratum in: Eur J Clin Nutr. 2015 Dec;69(12):1376. PubMed PMID: 19209185. 

8. Eaton SB, Strassman BI, Nesse RM, Neel JV, Ewald PW, Williams GC, Weder AB, Eaton SB 3rd, Lindeberg S, Konner MJ, Mysterud I, Cordain L. Evolutionary health promotion. Prev Med. 2002 Feb;34(2):109-18. Review. PubMed PMID: 11817903. 

9. Eaton SB, Cordain L, Eaton SB. An evolutionary foundation for health promotion. World Rev Nutr Diet. 2001;90:5-12. Review. PubMed PMID: 11545045. 

10. Cordain L, Miller JB, Eaton SB, Mann N. Macronutrient estimations in hunter-gatherer diets. Am J Clin Nutr. 2000 Dec;72(6):1589-92. PubMed PMID: 11101497. 

11. Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, Speth JD. Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr. 2000 Mar;71(3):682- 92. PubMed PMID: 10702160. 

12. Fenech M. Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food Chem Toxicol. 2002 Aug;40(8):1113-7. Review. PubMed PMID: 12067572. 

13. Fenech M, Ferguson LR. Vitamins/minerals and genomic stability in humans. Mutat Res. 2001 Apr 18;475(1- 2):1-6. PubMed PMID: 11295148. 

14. Fenech M. Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances. Nutr Res Rev. 2003 Jun;16(1):109-22. doi: 10.1079/NRR200359. PubMed PMID: 19079941. 

15. Fenech M. Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutat Res. 2012 May 1;733(1-2):21-33. doi: 10.1016/j.mrfmmm.2011.11.003. Epub 2011 Nov 7. Review. PubMed PMID: 22093367. 

16. Fenech M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat Res. 2001 Apr 18;475(1-2):57-67. Review. PubMed PMID: 11295154. 

17. Nutrition software analysis “Food Processor’ by ESHA Professional Nutrition & Fitness Software https:// www.esha.com/products/food-processor/ Twice Daily Multi™ 

18. Nutrition software analysis NutriBase Professional Nutrition & Fitness Software www.esha.com/products/food-processor/

19. C. Paul. Vitamin K-Chapter 136. Textbook of Natural Medicine (4th edition), editors Michal Murray, Joseph Pizzorno ISBN-13: 9781437723335 Publisher: Elsevier Health Sciences: 9/28/2012 

20. 5-methyltetrahydrofolate. Monograph. Altern Med Rev. 2006 Dec;11(4):330-7.

21. Mazza A, Cicero AF, Ramazzina E, Lenti S, Schiavon L, Casiglia E, Gussoni G. Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. J Biol Regul Homeost Agents. 2016 Jul-Sep;30(3):921-927. PubMed PMID: 27655522. 

22. Deshmukh US, Joglekar CV, Lubree HG, Ramdas LV, Bhat DS, Naik SS, Hardikar PS, Raut DA, Konde TB, Wills AK, Jackson AA, Refsum H, Nanivadekar AS, Fall CH, Yajnik CS. Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India. Eur J Clin Nutr. 2010 May;64(5):495-502. doi: 10.1038/ejcn.2010.15. Epub 2010 Mar 10.PubMed PMID: 20216560; PubMed Central PMCID: PMC2865445. 

23. Abdullah M, Jamil RT, Attia FN. Vitamin C (Ascorbic Acid). 2019 Jun 3. StatPearls Publishing; 2019 Jan-. Available from www.esha.com/products/food-processor/ PMID: 29763052.

24. White paper on 5-MTHF (Quatrefolic), by Gnosis. www.esha.com/products/food-processor/

25. Tam C, O’Connor D, Koren G. Circulating unmetabolized folic Acid: relationship to folate status and effect of supplementation. Obstet Gynecol Int. 2012;2012:485179. doi: 10.1155/2012/485179. Epub 2012 Feb 19. PubMed PMID:22529856. 

26. Sauer J, Mason JB, Choi SW. Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care. 2009 Jan;12(1):30-6. doi: 10.1097/MCO.0b013e32831cec62. Review. PubMed PMID: 19057184; PubMed Central PMCID: PMC2790187. 

27. Prinz-Langenohl R, Brämswig S, Tobolski O, Smulders YM, Smith DE, Finglas PM, Pietrzik K. [6S&91;- 5- methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->Tpolymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009 Dec;158(8):2014-21. doi: 10.1111/j.1476-5381.2009.00492.x. Epub . PubMed PMID:19917061; PubMed Central PMCID: PMC2807663.

28. Ashmead, H.D., Graff, D.J., Ashmead, H.H. (1985): Intestinal Absorption of Metal Ions and Chelates. Charles C. Thomas, Springfield, Illinois

29. Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013 Feb;18(2):144-57. PubMed PMID: 23914218; PubMed Central PMCID: PMC3724376. 

30. Anderson RA. Chromium as an essential nutrient for humans. Regul Toxicol Pharmacol 1997; 26:S35-41. 

31. Lamson DW, Plaza SM. The safety and efficacy of high-dose chromium. Altern Med Rev. 2002 Jun;7(3):218- 35. Review. PubMed PMID: 12126463. 

32. Hotz CS, Fitzpatrick DW, Trick KD, L'Abbe MR. Dietary Iodine and selenium interact to affect thyroid hormone metabolism of rats. J Nutr 1997; 127:1214-8. 

33. Arthur JR, Nicol F, Beckett GJ. The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. Biol Trace Elem Res 1992; 33:37-42. 

34. Nielsen FH. Is boron nutritionally relevant? Nutr Rev. 2008 Apr;66(4):183-91. doi: 10.1111/j.1753- 4887.2008.00023.x. Review. PubMed PMID: 18366532. 

35. Penland JG. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res 1998; 66:299-317. 

36. Biotin. Altern Med Rev. 2007 Mar;12(1):73-8. PubMed PMID: 17397270. 

37. B. Tan. The Truth about Vitamin E: The Secret to Thriving with Annatto Tocotrienols Kindle Edition. 2019. ISBN 1733887423, 9781733887427.

38. Pennington JA, Young BE. Total diet study nutritional elements, 1982-1989. J Am Diet Assoc 1991;91:179-83. 

39. NHANES (National Health and Nutrition Examination Survey) 2001-2002. www.esha.com/products/food-processor/

40. Murray CW, Egan SK, Kim H, Beru N, Bolger PM. US Food and Drug Administration’s Total Diet Study: dietary intake of perchlorate and iodine. J Expo Sci Environ Epidemiol. 2008 Nov;18(6):571-580. 

41. Iyenga GV, Wolfe WR, Tanner JT, et al. Content of minor and trace elements, and organic nutrients in representative mixed total diet composites from the USA. Sci Total Environ 2000;256:215-26. 

42. Zempleni J, Wijeratne SSK, Kuroishi T. Biotin. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:359-74

As we review published epidemiological data and various media reports, we share the broad concerns regarding the potential negative impacts of the developing COVID-19 pandemic and are taking measures to mitigate these for our practitioner customers, their patients, and our Adaptogen Research colleagues. This update summarizes these efforts to keep you informed. 

For our customers, we are implementing several immediate action plans to respond to the significant increase in orders for our products that support immune function. For these, we are increasing our production capacity and accelerating the inventory replenishment cycle for all products in this category. We will do our best to meet the sudden demand increase but have to acknowledge that some of our products and procurement of the ingredients used to manufacture them have fairly long lead times. It is impossible to precisely predict the extent and timing of the demand increase. Our manufacturing and distribution teams will work overtime and tirelessly to fill orders for these products to the best extent possible.

To help our practitioners we have developed a new Acute Viral Protocol which outlines preventative measures, technical background, and specific product recommendations for immunity support. 

Bisglycinate Chelates

Extensive clinical research and laboratory studies have shown that the amino acid glycine is the ideal size and type of ligand.[1&91; Glycine is an amino acid the human body produces naturally as a building block for larger protein chains.

A 2:1 ratio of glycine-to-mineral is the most nutritionally beneficial mineral chelate form, known as a mineral bisglycinate chelate.

There are three factors that make a bisglycinate chelate uniquely more biologically effective: 

1) the double ligand ratio protects the mineral as it passes through the stomach’s digestive process, 

2) the combined molecule is less than 500 Daltons in size, which is small enough to be absorbed by protein receptors in the intestinal tract intact. The mineral and ligand are then separated by metabolic processes and used by the body, and 

3) the molecule is neutral in charge, keeping it from interacting with food and drug content during digestion.

Adaptogen Research offers supplements with Chelated Minerals.  Chelated Minerals are well tolerated and very well absorbed.

Zinc Plus - this mineral may enhance immune function, stabilize blood sugar levels, and help keep your skin, eyes, and heart healthy.
Iron Chelate - crucial for maintaining healthy blood and delivering oxygen to tissues throughout the body. It is essential for proper energy levels, a healthy pregnancy, connective tissue integrity, cardiovascular health, normal cognitive development, and a strong immune system.
Mineral Support - ideal for use when mineral replenishment is desired.
Magnesium Buffered Chelate - one of the best absorbed forms of magnesium.

[1&91; Ferrari P et al. “Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate.” Biomed Pharmacotherapy, vol. 66, no. 6 (September 2012): 414-418